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NESC1088 UMIBIO.

UMIBIO, U Mill Bioassay Dosimetry Model

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1. NAME OR DESIGNATION OF PROGRAM:  UMIBIO.
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2. COMPUTERS
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No item

Machines used:

No specified machine
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3. DESCRIPTION OF PROGRAM OR FUNCTION

UMIBIO is an internal dosimetry model developed for estimation of the urinary concentration of natural uranium excreted at various times after an inhalation exposure to yellowcake (dried at high and at low temperatures) or ore dust. Calculations are based either on the single exposure intake variable or for continuous exposure on the intake rate variable. The user may change the default intake variables, specify  single versus continuous exposure and one or both exponential terms  for the systemic calculations.
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4. METHOD OF SOLUTION

UMIBIO uses the model developed by the Task Group on Lung Dynamics of the International Commission on Radiological Protection (ICRP) to describe the deposition and retention of inhaled radioactive material in the human respiratory tract and its clearance into the blood. The metabolic model assumes  that 11 percent of the uranium reaching the blood is deposited in kidney tissues and is subsequently excreted with a 15-day half-life. It is also assumed that 67 percent of the uranium reaching the blood is excreted within 24 hours without being deposited in any organ. The systemic uptake by all other organs is 22 percent; this uranium  is subsequently released back to the blood in accordance with a power function which may be represented by the sum of two exponential functions as recommended in ICRP-30.
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5. RESTRICTIONS ON THE COMPLEXITY OF THE PROBLEM

Maxima of -
   40-day time interval between specimen collections
Subsequent excretion of the uranium in organs other than the kidney, about 4 percent of that initially reaching the blood, is ignored.
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6. TYPICAL RUNNING TIME

Each sample problem required less than 9 CPU  seconds on an IBM3033.
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7. UNUSUAL FEATURES OF THE PROGRAM

New experimental data that illustrate the dependence of lung solubility in the thermal history  of the inhaled yellowcake are incorporated into the model.
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8. RELATED AND AUXILIARY PROGRAMS:
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9. STATUS
No status
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10. REFERENCES

- International Commission on Radiological Protection, Limits for
  Intakes of Radionuclides by Workers,
  ICRP Publication 30, Pergamon Press, New York, July 1978.
- International Commission on Radiological Protection,
  Recommendations of the International Commission on Radiological
  Protection,
  ICRP Publication 26, Pergamon Press, New York, January 1977.
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11. MACHINE REQUIREMENTS

1500 Kbytes of memory are required for compilation and execution on an IBM3033.
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12. PROGRAMMING LANGUAGE(S) USED
No specified programming language
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13. OPERATING SYSTEM UNDER WHICH PROGRAM IS EXECUTED:  MVS (IBM3033), VM/CMS (IBM4331).
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14. OTHER PROGRAMMING OR OPERATING INFORMATION OR RESTRICTIONS

The proprietary CA-DISSPLA graphics software (see http://www.gaeinc.com), used by UMIBIO, is not included. If CA-DISSPLA is not available or graphical output is not  required, the call to subroutine DISPLT should be eliminated from the MAIN routine.
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15. NAME AND ESTABLISHMENT OF AUTHORS

          R.E. Alexander, R.B. Neel, J.S. Puskin, and A. Brodsky
          Office of Nuclear Regulator Research
          U.S. Nuclear Regulatory Commission
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16. MATERIAL AVAILABLE
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17. CATEGORIES

Keywords: inhalation, radiation doses, respiratory system, uranium.